IP Archives of Cytology and Histopathology Research

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SLE associated haemophagocytic lymphohistiocytosis with disseminated histoplasmosis in a HIV seropositive patient

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Author Details: Iffat Jamal

Volume : 1

Issue : 2

Online ISSN : 2456-9267

Print ISSN : 2581-5725

Article First Page : 50

Article End Page : 52

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Abstract

Haemophagocyticlymphohistiocytosis (HLH) is an uncommon, life threating and likely underdiagnosed disease of diverse etiologies caused by a defective NK/T- cell cytotoxic pathway resulting in uncontrolled hypercytokinemialeading to end organ damage carrying a high mortality rate. Here we report HLH complicating SLE in a 42 years old female associated with disseminated histoplasmosis and accidentally detected as seropositive for HIV. This is extremely rare in the world literature.

Keywords: Haemophagocyticlymphohistiocytosis, Histoplasmosis, SLE