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Annals of Geriatric Education and Medical Sciences


PHARMACOLOGICAL INTEGRATION: ADJUNCT EFFECT OF DB14201, A NEW HERBAL FORMULATION DEVELOPED BASED ON AYURVEDIC PRINCIPLES, WHEN CO-ADMINISTERED WITH GLIBENCLAMIDE: RESULTS OF A PLACEBO CONTROLLED TRIAL


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Author Details: Geetha Krishnan Gopalakrishna Pillai

Volume : 2

Issue : 1

Online ISSN : 2348-7240

Print ISSN : 2348-7348

Article First Page : 2

Article End Page : 10


Abstract

There exist many therapeutic windows in the clinical area of Type 2 Diabetes. Traditional Medicines, including Ayurveda should be explored to identify safe and effective medicines for diabetes. DB14201 is an herbal formulation from Ayurvedic traditional knowledge and has been safely used by diabetics as a supplement drink for several years. Diabetics on hypoglycemic agents soon outgrow the effectiveness of an oral hypoglycemic agent and needs to add more of the same medicine or medicines with different mechanisms of action or insulin. A safe herbal add-on to oral hypoglycemics which can improve the efficacy of glycemic control and offer longer window of time for a specific dosage would greatly improve the current management of diabetes. The current study proves that DB14201 when used with glibenclamide as an add-on improves its efficacy in glycemic control as evidenced by comparatively lower fasting and post prandial blood sugar level in the study group as against the placebo group. The addition of DB14201 also helps in reduction of HbA1c levels by nearly 1% points over a period of 90 days.