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Indian Journal of Clinical Anaesthesia


A prospective comparative study to compare cardiovascular response to laryngoscopy and intubation after induction of anaesthesia by propofol and etomidate


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Author Details: Kaushal Kabir, Gaurav Acharya, Manish Banjare, KK Arora, Sachin Kumbhare

Volume : 4

Issue : 1

Online ISSN : 2394-4994

Print ISSN : 2394-4781

Article First Page : 41

Article End Page : 45


Abstract

Context: Etomidate is having more stable cardiovascular response as compared to propofol during laryngoscopy and intubation.
Aims: The present study compares the effect of propofol and etomidate on cardiovascular response to laryngoscopy and intubation.
Settings and Design: This prospective comparative study was conducted at a tertiary care hospital in central India.
Methods and Material: Hundred healthy patients of both sex aged between 18 to 45 years, ASA physical status I & II, scheduled for elective surgery under general anaesthesia were selected. Patients in group P (n=48) were induced with propofol 2.5 mg/kg i.v. and group E (n=47) were induced with etomidate 0.3 mg/kg i.v. Patients’ haemodynamic and cardiovascular parameters were recorded before induction (T1), before intubation (T2) and 1, 3, 5 and 10 minutes afterwards. The haemodynamic parameters before induction i.e. T1 was taken as baseline.
Statistical analysis used: The data was collected using Microsoft Excel software and was analysed using SPSS software version17.0.
Results: There was significant difference regarding systolic blood pressure, diastolic blood pressure and mean arterial pressure among two groups. Hypotension was seen in 18.8% patients in group P after induction while there was none in group E.
Conclusions: Etomidate is having more stable cardiovascular response as compared to propofol during laryngoscopy and intubation.

Keywords:
Etomidate, Hypotension, Laryngoscopy propofol.
Key Messages: A comparison of the effect of propofol and etomidate on cardiovascular response to laryngoscopy and intubation