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Indian Journal of Clinical Anaesthesia


PREANAESTHETIC MEDICATION WITH DIFFERENT DOSES OF INTRANASAL MIDAZOLAM: A RANDOMIZED CLINICAL STUDY IN CHILDREN


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Author Details: Mukesh Somvanshi, Archana Tripathi, Anil Rajoriya

Volume : 2

Issue : 1

Online ISSN : 2394-4994

Print ISSN : 2394-4781

Article First Page : 1

Article End Page : 5


Abstract

Background: Midazolam is often used for premedication in children. We investigated the efficacy of different doses of intranasal midazolam for premedication in 75 children, ASA physical status I and II, aged 3 to 10 years of either sex undergoing various elective surgical procedures.
Methods: In a randomized, double blind, placebo controlled design, all children were allocated to one of the three groups of 25 each. Group – A received 0.2 mg/kg intranasal midazolam (5mg/ml). Group – B received 0.3 mg/kg intranasal midazolam (5mg/ml). While Group – C received intranasal normal saline. After 20 minutes of premedication, sedation scores and ease of separation from parents were noted. Children’s response at the time of intravenous cannulation and face mask application was also measured.
Results: Sedation scores in group A and B were excellent (3.64 ±0.5 & 3.76 ±0.7 respectively) compared to group C (1.24 ±0.4). Separation of children from their parents was easier in group A & B than in Group C. In group A & B, children were calm on intravenous cannulation and face mask application.
Conclusion: We conclude that intranasal midazolam is effective and very well accepted premedication drug in children.

Key words: Children, Premedication, Intranasal route and Midazolam.