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Indian Journal of Clinical Anatomy and Physiology

Effect of Testosterone and Estrogen Ratio - An indicator of Benign Prostatic Hyperplasia (BPH)

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Author Details: Qhurrathul Ain Sayeed, Farisa Khatoon, Farah Bahmed, Maria Kaleem

Volume : 3

Issue : 2

Online ISSN : 2394-2126

Print ISSN : 2394-2118

Article First Page : 125

Article End Page : 130


Background: Benign prostatic hyperplasia (BPH) is one of the most common disease and major cause of morbidity in elderly men. Prostatomegaly often used interchangeably with BPH, is a prominent feature of the disease. Although sex steroid hormones play a vital role in prostate growth, their clinical significance is not completely clear. The phenomenon may be correlated with changes of sex hormone in serum of elderly population. Hence, the objective of this study was to study the roles of serum hormones levels – Testosterone (T) and Estradiol (E2) in elderly patients aged 60-75 years who are diagnosed with benign prostatic hyperplasia (BPH) and to understand the correlation between T/E2 ratio over age as markers of prostate disease.
Methods: To conduct this case control study, a population of 30 patients with benign prostatic hyperplasia (BPH) had been selected and 30 well-matched males without BPH as a control group.
Result: Testosterone level declined with age, but serum estrogens level remains unaltered so estrogen may be involved in the development of BPH.
Conclusion: The present study suggests that testosterone estrogen ratio can be an indicator of BPH in patients above 45 years of age.

Keywords: Benign prostatic hyperplasia (BPH), Testosterone T and Estradiol (E2).