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Indian Journal of Clinical Anatomy and Physiology


Anti-Diabetic Activity of Aqueous extract of aerial parts of Allamanda Cathartica Linn in Diabetic Rats Induced by Alloxan


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Author Details: Satish S, Chitra

Volume : 2

Issue : 2

Online ISSN : 2394-2126

Print ISSN : 2394-2118

Article First Page : 50

Article End Page : 54


Abstract

Diabetes is a group of diseases marked by high levels of blood glucose, also called blood sugar, resulting from defects in insulin production, insulin action, or both. In modern medicine no satisfactory effective therapy is yet available to cure diabetes mellitus. Though several oral hypoglycaemic agents are used for the management of diabetes mellitus, there are several drawbacks. They are also not approved for the treatment of women who are pregnant with diabetes. Thus, alternative therapy is required. So the search for newer anti-diabetic drugs with minimum or no side effects from herbal plants is a challenge as per WHO recommendations.
The present study was aimed to evaluate the anti-diabetic potency of Allamanda cathartica on the blood glucose level in alloxan induced diabetic rats. Diabetic Albino Wistar strain rats were treated with standard drug Glibenclamide and test drug Allamanda cathartica at 200mg (low dose) and 400mg (high dose). The hypoglycemic effect was determined in the rats and the efficacy of the test drug was compared to the standard drug Glibenclamide. Allamanda cathartica was orally administered for 28 days in alloxan induced diabetic rats. At the end of the study duration, blood glucose level and body weight were statistically analyzed. Based on these results of the study Allamanda cathartica produced a significant reduction in blood glucose levels, serum enzymes (SGPT and SGOT) and slight increase in the body weight when compared with diabetic control rats. Hence the present research work proved that the Allamanda cathartica possess hypoglycemic effect.

Keywords:
Diabetes mellitus, Alloxan, Glibenclamide, Allamanda cathartica, Blood glucose level, Body weight, Anti-diabetic activity