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Indian Journal of Clinical Anatomy and Physiology


QT corrected and QTc dispersion across different phases of menstrual cycle- A cross-sectional study


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Author Details: Nirmala S. Anand*,Shivaprasad S. Goudar

Volume : 5

Issue : 4

Online ISSN : 2394-2126

Print ISSN : 2394-2118

Article First Page : 478

Article End Page : 482


Abstract

Introduction: The gonadal hormones accompanying the menstrual cycle in a female affect the ventricular repolarization regionally in the cardiac muscle as well as affects its recovery time both of which are QTc AND QTd measured conventionally using a non-invasive ECG. A prolonged QTc and QTd are predictors of cardiac morbidity and mortality.
Aim: The aim of the present study was to examine whether the cardiac ventricular repolarization is altered during different phases of menstrual cycle by the endogenous gonadal hormones.
Materials and Methods: Thirty eumenorrhic females were examined using 12 lead ECG during the follicular and luteal phases of menstrual cycle.
Statistical Analysis: Data was analysed statistically using student’s paired t-test.
Results: It was observed that the heart rate in follicular phase was (78.8 ±7.48) while in luteal (84 ± 8.17), R-R interval in follicular was (82±5.89) while in luteal phase was (77±3.69) QT interval in follicular was (0.39±0.09) while in luteal phase was (0.33±0.08), QTc in follicular was (0.43±0.03) while in luteal phase was (0.39±0.03), QTd in follicular was (67 ± 2.30) while in luteal phase was (58±4.08).
Conclusion: We hence elucidate interactions between the sex steroids and cardiac conduction dynamics which is characterized by a prolonged QTc and QTd during the follicular phase.

Keywords: Endogenous, Gonadal, Menstrual cycle, Repolarization

Doi :-https://doi.org/10.18231/2394-2126.2018.0111