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Indian Journal of Clinical Anatomy and Physiology


Expression of Glial Fibrillary Acidic Protein (GFAP) in the Trigeminal Ganglion of Male Wistar Rats


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Author Details: P.K. Sankaran, M.Kumaresan, G. Karthikeyan, Yuvaraj M

Volume : 2

Issue : 3

Online ISSN : 2394-2126

Print ISSN : 2394-2118

Article First Page : 145

Article End Page : 147


Abstract

Background Significance: The pseudounipolar neurons in the sensory ganglia are wrapped by small satellite cells which play a similar role like Schwann cells in the peripheral nervous system. The pseudounipolar cells of trigeminal ganglion are surrounded by a capsule formed by satellite glial cells. These satellite glial cells play important role in maintaining normal functions of the neuron.

Aim & Objective: To localise GFAP in satellite glial cells of trigeminal ganglion.
Material & Methods: Six male wistar albino rats trigeminal ganglion were collected and immunohistochemically stained for GFAP in six male wistar albino rats.
Result: GFAP was localised in the cytoplasm of satellite glial cells surrounding the neurons. GFAP was also localised around Schwaan cells of an axon.
Discussion: GFAP is an intermediate protein which can get up regulated due to peripheral axonal injury. This GFAP can trigger mediators of inflammation and create a neuralgia or migraine like conditions.
Conclusion: This study concluded that satellite cells are type of glial cells that express GFAP. This GFAP was also expressed by Schwaan cells surrounding the axon.

Keywords: GFAP, Trigeminal ganglion, Satellite glial cells, Pseudounipolar neurons