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International Journal of Clinical Biochemistry and Research


Association of Serum Electrolytes and Urea Levels with Cardiac Markers in Acute Myocardial Infarction


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Author Details: Rakesh Mudaraddi, Shrirang Prahlad Kulkarni, Dhiraj Jayantilal Trivedi, Vidya Shankargouda Patil, Pr

Volume : 2

Issue : 4

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 233

Article End Page : 235


Abstract

Background: The alterations (increase or decrease) of intracellular and extracellular enzymes or components in developing phase of disease are called markers. Variations in biochemical markers like Cardiac Troponins-I (cTnI), Creatine kinase (CK) and its isoform Creatine kinase-MB (CK-MB) may correlate with the extent of myocardial damage in Acute Myocardial Infarction (AMI). Association of serum electrolytes and urea levels were undertaken in this study as adjunctive parameters along with cardiac markers, which probably helps in better prognosis of AMI.
Materials and Methods: 120 subjects were included in this study and divided equally as study and control groups. Estimation of cTnI, CK, CK-MB, Serum sodium, potassium, chloride and urea were done in all the participants. Data were compared by using student `t’ test and chi-square test (SPSS version 17.0).
Results: There were statistically significant decreased levels of serum sodium (p<0.001), potassium (p<0.001) and elevated levels of urea (p<0.001) observed in AMI. But, the levels of serum chloride didn’t show any significant correlation between case and control groups.
Conclusion: The present study was conducted to make an effort to find out association of abnormal levels of electrolytes and urea in AMI. Further studies are required to know the role of these correlations in prognosis of clinical condition.

Doi No:-10.18231