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International Journal of Clinical Biochemistry and Research


A Study of Renal Dysfunction in Chronic Alcoholic Men in a Tertiary Care Hospital


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Author Details: Swetha Singaravelu, Shantha Kumari

Volume : 2

Issue : 4

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 246

Article End Page : 249


Abstract

Background: Alcoholism is a serious social threat in our country leading to morbidity and mortality in various aspects. It causes damage to almost all the systems of the body including central nervous system, cardiovascular system, liver and kidneys out of which liver being the most commonly affected. However renal dysfunction is usually noticed during the terminal stages by then the other systems have already damaged.
Aims and Objectives: This study is to measure the parameters of renal functions like serum urea, creatinine, creatinine clearance, sodium, potassium, calcium and phosphorus in chronic alcoholic men without dependence features and to show the need to assay simple renal function tests periodically as damage to the kidneys are usually missed.
Materials and Methodology: The study was conducted in 60 middle aged men of age 30-50 yrs in Dr. B. R. A. M. C. H from outpatient and inpatient departments. Among them 30 were controls and 30 were chronic alcoholics. Informed consent obtained from all subjects. A detailed history was obtained by questionnaire and serum collected from fasting sample was measured for the following analytes urea, creatinine, creatinine clearance, sodium, potassium, calcium and phosphorus.
Results and Conclusion: The serum urea and creatinine values are significantly raised in cases of chronic alcoholic with p value of <0.01. The creatinine clearance is significantly lowered in cases of chronic alcoholic intake with p value of 0.006. The levels of serum sodium, potassium, calcium and phosphorous are significantly lowered when compared to the controls with a p value of <0.01. This strongly suggests chronic alcohol consumption is associated with renal dysfunction.

Key Words: Alcoholics, Urea, Creatinine, Creatinine clearance, Sodium, Potassium, Calcium and Phosphorus.