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International Journal of Clinical Biochemistry and Research


A study to assess the relation between severity of hypothyroidism and Lipid parameters


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Author Details: Kavitha M M, Chandrashekharayya S H, Sangappa V Kashinakunti, Manjula R, Gurupadappa K

Volume : 3

Issue :

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 23

Article End Page : 27


Abstract

Background: Hypothyroidism is associated with dyslipidemia. The present study was conducted to assess the relation between hypothyroidism and lipid parameters and lipid ratios. It is also done to assess the severity of hypothyroidism on lipid parameters.
Methods: Study comprises of 120 participants were divided into four groups depending on TSH levels, each group comprising of 30 participants. Group-1 euthyroid as controls, group-2 hypothyroid patients with TSH levels between 6-20 mIU/mL, group-3 TSH levels between 21-50 mIU/mL and group-4 consists of hypothyroid patients with TSH levels of > 50 mIU/mL. Fasting venous blood was collected from all the participants and analysed for estimation of thyroid profile and lipid profile. Lipid ratios were calculated.
Results: There was significant (p < 0.05) increase in total cholesterol, triglycerides, LDL-C and HDL-C in all the groups compared to group-1 i.e controls. There was significant increase (p<0.05) in lipid ratios. There is positive correlation between TSH and lipid parameters.
Conclusion: Our study shows hypothyroid patients show dyslipidemia and the effect of hypothyroidism on lipid parameters is more marked in patients with higher serum TSH levels. By calculating the lipid ratios from lipid parameters are better indicators of dyslipidemia and cardiovascular risk in hypothyroid patients.

Key words:
Dyslipidemia, Hypothyroidism, Lipid ratios