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International Journal of Clinical Biochemistry and Research


Nitric oxide levels in periodontitis with relation to obesity


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Author Details: Pradnya Shree Dhotre, Rajashree Basawraj Bhogade, Abdul Kayyum Shaikh

Volume : 3

Issue :

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 50

Article End Page : 54


Abstract

Background: There is growing evidence that nitric oxide (NO) is critically involved in obesity and its clinical consequences like cardiovascular disease, hypertension and diabetes. However the role of nitric oxide in oral condition like periodontitis in relation to obesity is not clearly understood. Hence we have attempted to elucidate role of serum and salivary nitric oxide in obese and non-obese periodontitis patients.
Method: We investigated 100periodontitis patients; out of which 50 were obese (Group C) and 50 were non-obese patients (Group B) along with 50 normal weight, age matched healthy controls (Group A). Various dental and clinical parameters as well as body measurements were assessed.
Results: Group B and Group C showed a marked increase (P <0.001) in clinical attachment loss and probing depth when they are compared with Group A. Group B and Group C patients are also compared for body mass index and waist circumference with Group A.BMI and WC was found to be non significant in Group B when compared with Group A. Group C patients exhibited a highly significant increase in BMI and WC when compared with Group A. Group C patients also showed a highly significant increase in BMI and WC when compared with Group B.
The study also documented a significant increase in serum & salivary nitric oxide levels in Group B and C when compared to Group A. (P<0.001).Obese periodontitis patients (Group C) revealed highly significant increase (P <0.001) in nitric oxide levels than non-obese periodontitis patients (Group B).
Conclusion: Obesity can be considered as an important contributing factor in enhancing the severity of periodontitis as well as nitric oxide production in these patients.

Keywords:
Nitric oxide, Obesity, Periodontitis