International Journal of Clinical Biochemistry and Research


STUDY OF HIGH SENSITIVE C REACTIVE PROTEIN AND LIPID PROFILE IN PSORIASIS


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Author Details: Savitha Jagannath, Meera. S, Shubha Jayaram, Sahithya C. S.

Volume : 1

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 1

Article End Page : 6


Abstract

Psoriasis is a chronic, inflammatory skin disease characterized by epidermal hyper proliferation, differentiation and lymphocytic infiltration predominantly of T lymphocytes. Evidence have shown that psoriasis is an independent risk factor for cardiovascular diseases. hs-CRP is an acute phase reactant and best biomarker of inflammation that has been associated with cardiovascular disease(CVD) risk .Hence this study was undertaken to evaluate hs-CRP, lipid profile and Novel Lipid Indices in psoriatic patients.
Materials and Methods: The study group consisted of 47 psoriasis cases and 47 healthy controls. PASI (Psoriasis Area and Severity Index) Score was done to assess severity of Psoriasis. Lipid profile (Total Cholesterol, Triglycerides, LDL and HDL) was measured in fully automated analyser. hs-CRP was measured by immuno turbidimetric method. Statistical analysis was done by using SPSS-16 version. Results: Statistically significant (p<0.05) increase of hs-CRP was seen in cases (3.6595±3.038) when compared to controls (1.595±1.014). Cholesterol, triglycerides and LDL were found to be increased in cases compared to controls which was statistically significant (p<0.05), whereas HDL levels were not statistically significant. hs-CRP levels positively correlated with severity of psoriasis. Among lipid indices CRI-I and CRI-II showed significant increase in cases compared to controls.
Conclusion: Present study suggests that psoriatic patients have significant dyslipidaemia which is proatherogenic in nature, which correlated significantly with inflammatory marker like hs-CRP. Early screening of patients helps in early intervention which in turn can reduce mortality.