International Journal of Clinical Biochemistry and Research


RELATIONSHIP BETWEEN HUMAN AGE-RELATED CATARACTS AND SOME SERUM ROUTINE BIOCHEMICAL PARAMETERS OF INDIAN POPULATION


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Author Details: Chandrasekar R, Dhanarajan MS, Lalitha Prajna S and Srinivasan M

Volume : 1

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 10

Article End Page : 15


Abstract

Formation of cataract is one of change in human aging process. Although it is common in all individuals the rate of development differ from each other due to many factors like life style, environmental and hereditary causes. All these factors are believed to make cataract through modified serum biochemical parameters and or capable of making impact on serum biochemical parameters. Hence, a study was programmed to measure the level of biochemical parameters for two study groups having clinically negative cataract as normal control group and positive cataract as diseased group. All patients were natives of south India and having the same ethnicity. About 100 samples in each groups were planned. Biochemical data were retrieved from medical records and analyzed by statistical tools, unpaired t test with Welch's correction - Two-tailed - P < 0.05 and F test to compare variances. Results indicated that there is a significant difference in serum biochemical parameters between normal control and diseased groups. The observed elevated parameters in diseased groups were Total protein, Cholesterol, LDL, CRP, SGOT, SGPT, ALP, LDH, Calcium, Copper, Magnesium and Iron in both T test and F test. This study suggest that monitoring these parameters at regular intervals may be helpful to prolong the duration of obvious development of cataract which require medical intervention.

Keywords: Cataract, Diabetic, Lipid, Liver, minerals, Biochemical parameters, Indian population