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International Journal of Clinical Biochemistry and Research


Oxidative stress in post menopausal women with cardiovascular risk factors


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Author Details: Subrat Kumar Tripathy, Viyatprajna Acharya, Sarthak Ranjan Nayak, Pramila Kumari Mishra

Volume : 3

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 67

Article End Page : 71


Abstract

Background: Menopause is a normal occurrence in the life of every woman. As the life expectancy of woman all over the world now increases, a woman has to spend almost 1/3rd of her life in menopause years. Along with the increase in life expectancy the cardiovascular disease is increasing.
Objectives: To study the association between oxidative stress and various cardiovascular risk factors in post-menopausal women.
Methods: 50 postmenopausal women with cardiovascular risk factors like hyperglycemia, hypertension, high Body Mass Index and Hyperlipidaemia were selected as cases and compared with 50 age matched apparently healthy controls. Malon-di-aldehyde (MDA) was taken as the marker for oxidative stress and vitamin E & vitamin C were taken to assess antioxidant status. Student’s t-test was applied to compare different parameters between the groups and Pearson’s correlation was applied to see the correlation with different parameters in the case group.
Results: It was found that MDA values in postmenopausal women with cardiovascular risk factors were significantly higher as compared to the post menopausal women without cardiovascular risk factors (p < 0.001). There is significant decrease in vitamin E and C values in cases (p is < 0.001 and < 0.01 respectively). Comparing the various oxidative markers in cases and control it was found that MDA values have a significant negative correlation with vitamin E and C (r= -0.4 and r= -0.7 respectively). Whereas correlation between changes in Vitamin E and vitamin C was positive but not significant (r= +0.2, p ˃0.05).
Conclusion: Antioxidant medication and other measures can be adopted to reduce oxidative stress in post menopausal women with cardiovascular risk factors and reduce the morbidity and mortality associated with cardiovascular disease.

Key words:
Menopause, Malon-di-aldehyde (MDA), Vitamin E, Vitamin C, Cardiovascular risk factors