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International Journal of Clinical Biochemistry and Research


Perinatal outcome in relation with laboratory findings in pregnancy induced hypertension(PIH)


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Author Details: Liggy Andrews, Haridas Namboothiri, Smruti Vaishnav

Volume : 3

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 105

Article End Page : 100


Abstract

Background: Perinatal mortality is an important indicator of the status of maternal and child health, the conditions of obstetric care and the level of economic development of a community. The perinatal mortality rate (PMR) reflects both the characteristics of reproductive health and the quality of antenatal care, delivery, and newborn care.
Objective: To find out the corelation between laboratory parameters with perinatal outcomes in PIH cases.
Method: 320 patients having an average systolic blood pressure ≥ 140 mm hg and/or diastolic blood pressure ≥ 90 mm Hg  were included in the study and biochemistry parameters like serum AST, ALT analysed by UV kinetic, LDH by UV kinetic IFCC, Uric acid by modified Trinder’s method and calcium by arsenazo III methods, were measured by Xl 300 autoanalyzer.
Result: In our study overall incidence of PIH was 14.3 %. Maternal death occurred in 09 cases(2.8%). Perinatal mortality occurred in 86(23.3%) with 57(17.8%) Stillbirth and 29(9.0%) Neonatal deaths. Low birthweight<2.5Kg 73(84.8%) was the common complication observed followed by prematurity 64(74.4%) and IUGR 40(46.5%) leading to perinatal deaths. PMR increased as the BP increased. It was 14.9% for BP 140/90 to 149/94, to 57.3 % at BP >160/110 and above (Table 2). Perinatal death increased significantly in PIH women with increased levels of serum AST, ALT, uric acid, LDH and with a significant decrease in serum calcium levels. Perinatal death occurred in 63(73%) cases with Uric acid >6.0 mg/dl, 48(55.8%) in cases with > 600U/l LDH and in 48(55.8%) cases with < 8.0 mg/dl Calcium.
Conclusion: A positive correlation has been made out between serum AST, ALT, uric acid, LDH, calcium and perinatal deaths in relation to the severity of PIH and these may be useful markers and diagnostic tools for predicting the progression of PIH.

Keywords:
Preeclampsia, uric acid, LDH, calcium, Perinatal mortality