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International Journal of Clinical Biochemistry and Research


“Ratio of AST/ALT and serum gamma glutamyl transferase (GGT) activity in chronic alcoholics and acute viral hepatitis”


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Author Details: Narendra S. Dange, Abhay N. Nagdeote, Rajeshree A. Nandanwar

Volume : 3

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 186

Article End Page : 189


Abstract

Background: Liver enzymes AST, ALT, GGT (Gamma Glutamyl Transferase), ALP levels in serum was measured in Chronic alcoholics and acute viral hepatitis and controls. Analysis was done to find out the significance of liver associated enzyme levels among the chronic alcoholics and viral hepatitis.
Materials and Methods: Fifty one chronic male alcoholics aged between 30-60 years and thirty six patients with viral hepatitis who were admitted to the medicine ward at Govt. Medical College, Jagdalpur, Chhattisgarh during March 2014 to December, were the subjects. Forty eight age-matched, normal, healthy controls were also included in the study. GGT, ALT, AST and ALP were assayed in the clinical biochemistry laboratory using auto analyser by kit method (By Accurex Co. kinetic method).
Results:  Chronic alcoholics (n=51) subjects show increased serum levels of GGT (185.42±58.32), ALT (83.43±32.48), AST (139.29±64.34), ALP (173.42±31.62),(p values < 0.05) as compared to controls which was statistically significant. In Acute Viral hepatitis (n=36), all enzymes levels were statistically increased significant as compared to controls. But the levels of GGT (108.47±31.54) & ALT (293.43±54.62) (p value < 0.01) were more significant in viral hepatitis as compared to controls and chronic alcoholics.  Ratio of AST/ALT was significantly increased (1.66, p value < 0.05) as compared to controls (0.92). But the ratio of AST/ALT was more significantly decreased (0.49, p value < 0.01) in acute viral hepatitis as compared to chronic alcoholics.
Conclusion: Serum GGT and the ratio of AST/ALT increased much more in chronic alcoholics than viral hepatitis. ALT level increased much more significantly in viral hepatitis, while the ratio of AST/ALT more significantly decreased.

Keywords
: Gamma Glutamyl Transferase, Viral hepatitis, Chronic alcoholics