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International Journal of Clinical Biochemistry and Research


Usefulness of serum gamma glutamyl transferase in assessing severity of preeclampsia


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Author Details: Sumathi M.E, Ruta Ujjval Joshi, Gomathy E, Shashidhar KN

Volume : 3

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 245

Article End Page : 249


Abstract

Introduction: Pre-eclampsia is a multisystem disorder, unique to pregnant women after twenty weeks of gestation.  In India the incidence of pre-eclampsia is reported to be 8-10% of the pregnancy. It contributes significantly to maternal and perinatal mortality and morbidity. Among the biochemical markers, uric acid and LDH have been extensively studied in pregnancy induced hypertensive disorders. Very limited studies are available about the role of GGT in preeclampsia. This study intended to know the correlate the biochemical levels of GGT, LDH and Uric acid with the severity of pre-eclampsia.
Materials and Methods: 50 pregnant women clinically diagnosed as preeclampsia after 20 weeks of gestation between 18-35 yrs of age group. Preeclampsia is diagnosed based on the American College of Obstetrics and Gynecology (ACOG) criteria. Cases were classified into two groups mild preeclampsia (Group II) and severe preeclampsia (group III). 50 Age matched healthy normotensive pregnant women after 20 weeks of gestation enrolled in the study as controls and categorized as Group I.
Results: Serum AST, ALT, LDH and uric acid levels were increased in cases compared to controls. Serum LDH is significantly increased in severe pre-eclamptic cases compared to controls. There was no significant correlation observed between GGT with serum LDH and Uric acid. ROC curve indicates that Serum LDH is the better indicator of severity in preeclampsia when compared to serum GGT and uric acid.
Conclusion: Serum LDH and uric acid are the better indicators of severity in preeclampsia when compared to serum GGT.

Key words:
Endothelial dysfunction, GGT, LDH, Preeclampsia, Uric acid