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International Journal of Clinical Biochemistry and Research


Serum ferritin as a biomarker in hematological conditions


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Author Details: Dhanunjay Kalvakuri, Srinivasa Rao K, Manjunath G.A

Volume : 3

Issue : 3

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 272

Article End Page : 276


Abstract

Objective: This study is to evaluate significance of serum ferritin in differentiating between different hematological conditions.
Methods: This is a prospective study conducted on children aged between 1 to 12 years attending Pediatric OP and IP of Navodaya Medical College, Raichur for period of one year. 200 children who fulfilled WHO criteria for anemia were taken as cases and 200 normal healthy children of same demographic data were taken as controls. Serum ferritin levels were compared between the normal healthy children and children with different types of anemias.
Results: The mean value of serum ferritin in normal controls (106.8 ± 38.0ng/ml), in IDA (5.1 ± 2.3ng/ml), in Dimorphic anemia (330±40ng/ml), in Sickle cell anemia (430±83ng/ml), in Thalassemia major (1520±230 ng/ml), and in leukemias (1550±140ng/ml)
Conclusion: Serum ferritin is moderately raised in dimorphic anemia, in Sickle cell anemia, Thalassemia and leukemias it is significantly raised. And we found that serum ferritin is the most sensitive and reliable parameter compared to other parameters in iron profile in evaluating both iron deficient and iron overload conditions.

Keywords: 
Serum Ferritin, Thalassemia, Sickle cell anemia, Dimorphic anemia, leukemia