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International Journal of Clinical Biochemistry and Research


To study an alteration in biochemical parameters in acute and chronic phase of respiratory acidosis and alkalosis


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Author Details: Anita M Raut, D.V. Andure, Dilip Mhaisekar, Smita Mhaisekar, R.K. Padalkar

Volume : 3

Issue : 3

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 280

Article End Page : 284


Abstract

Introduction: The primary abnormality in respiratory acidosis is retention of CO2 (increased H2CO3) due to impaired alveolar ventilation resulting in a rise in pCO2 causing acidemia. However, respiratory alkalosis occurs when there is decrease in H2CO3 concentration. A fall in pCO2, reduces the ratio of carbonic acid to bicarbonate resulting in alkalemia.
Aim: To study variations in biochemical parameters in respect to respiratory acidosis and alkalosis.
Material and Methods: The biochemical parameters of respiratory acidosis and alkalosis like blood pH, concentration of CO2, pO2, pCO2, level of HCO3-.
Results: The studied components of respiratory acidosis and alkalosis were found to be highly significant in chronic conditions of respiratory acidosis and alkalosis (p<0.01) than acute condition of respiratory failure when compared with the healthy controls.
Conclusion: In this study, we observed that there is marked increase in product of metabolism in acute and chronic phase of respiratory syndrome when compared with the healthy controls.

Keywords:
Respiratory acidosis, respiratory alkalosis, blood pH, pO2, pCO2, HCO3-