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International Journal of Clinical Biochemistry and Research


Role of biomarker of Oxidative stress in preeclampsia


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Author Details: Smita Bahediya, Gaurav Modi, Shobha Chokshi

Volume : 3

Issue : 3

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 312

Article End Page : 315


Abstract

Objective: To evaluate the role of biomarker of oxidative stress in predilection of pregnancy induced hypertension.
Material and Methods: A sample of 200 pregnant women was examined at department of Gynecology and obstetrics at tertiary care hospital from the period of July 2008 to march 2010. Pregnant women were divided into three groups including 100 normal healthy pregnant women which were controls. Another 100 pregnant women having increased blood pressure and proteinuria divided into two groups depend on severity on B.P. and urinary proteinuria. Groups were compared for the levels of antioxidant biomarker for the statistical analysis, suitable test for these qualitative variables with 5% significance were used.
Results: Preeclampsia remains a frequent and potentially dangerous complication of pregnancy. The cause remains largely unknown, but oxidative stress and a generalized inflammatory state common are features. In present study, patient with pregnancy induced hypertension shows MDA levels were found significantly higher, while Vitamin C and Vitamin E levels are significantly lower compared with normal healthy pregnant women.
Conclusion: A combination of vitamins C and E administration can be found promising for prevention of preeclampsia. As small study group, our study has a limited statistical power if significance several multicenter randomized clinical trials are further required.

Key Words:
Preeclampsia, Oxidative stress, Antioxidants, Free radicals