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International Journal of Clinical Biochemistry and Research


Prevalence of overt and subclinical thyroid disease in patients tested for thyroid profile in CIMS Bilaspur (C.G.)


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Author Details: Vikas Kumar Gupta, Prashant Nigam, S.K.B. Patil

Volume : 3

Issue : 3

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 343

Article End Page : 347


Abstract

Background: Thyroid diseases are common worldwide. In India too, there is a significant burden of thyroid diseases. According to a projection from various studies on thyroid disease, it has been estimated that about 42 million people in India suffer from thyroid diseases. Thyroid dysfunction has varied impact on pregnancy outcome. Thyroid disorders are amongst the most common endocrine diseases in India. The prevalence and pattern of thyroid disorders depends on sex, age, ethnic and geographical factors and especially on iodine intake. A high iodine intake is associated with lower prevalence of goitre and higher prevalence of hypothyroidism. This study was designed to address this question. We undertook this study to provide reference data for TSH, T4 and T3 in women of this region and evaluate their status of thyroid function.
Material and Methods: The study was carried out at Department of Biochemistry, Chhattishgarh Institute of medical sciences, Bilaspur (C.G.). The study was conducted on 1100 subjects of age group 15- 65. The thyrotropin, TSH levels of serum samples were analysed using kits (Diagnostic Product Corporation (DPC), LosAngeles, USA) on the I25 GAMA Counter. Serum T3 and T4 were performed using competitive RIA technique and serum TSH was performed using IRMA technique.
Result and Discussion: Of the 1100 total subjects in the age range 15–65 years, 24.1% had thyroid dysfunction and 75.9% were euthyroid. The prevalence of thyroid dysfunction in group I, 19% hypothyroid, 5% hyperthyroidism 75.9% euthyroid and in group II, 16% hypothyroidism, 4% hyperthyroid and 79.5 were euthyroid. The finding that a large number of women unknowingly have laboratory evidence of thyroid dysfunction supports the usefulness of screening for early detection. We hope to extend the study to a larger cross section of men and women in this region keeping in mind environmental and etiopathological factors like auto immunity, drugs, Iodine and non-thyroidal illness.

Keyword:
Subclinical hypothyroidism, Prevalence, Thyroid stimulating hormone, Radioimmuno Assay, Thyroid dysfunction