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International Journal of Clinical Biochemistry and Research


Association between high sensitive c reactive protein and lipid profile in coronary artery disease with type 2 diabetes mellitus


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Author Details: Vinod V Wali, Smita S. Patil

Volume : 3

Issue : 4

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 472

Article End Page : 476


Abstract

Background: Diabetes, specifically type 2 diabetes mellitus (T2DM), is one of the most challenging health problems in the 21st century. The cause of higher prevalence of coronary artery disease (CAD) in T2DM is multifactorial. Increased concentrations of acute phase proteins particularly high sensitive high reactive protein (hsCRP) have been reported in patients with T2DM.
Aim: To know the association of hsCRP with other risk factors for CAD in T2DM.
Materials and Methods: This was a case control study conducted at tertiary care hospital in South India from May 2014 to May 2015. 100 patients (69 males and 31 females) aged between 30-60 years of either sex with type 2 diabetes mellitus and diagnosed for coronary artery disease (clinically and by ECG findings) were selected as cases. 100 controls (64 males and 36 females) without T2DM were chosen. Student ‘t’ test used to test the significance, between cases and controls and P values of <0.05 were considered as statistically significant, P values of <0.01 was considered highly significant. Correlation  coefficients  (r  values)  were  used  to  study  the association  of  hsCRP  with  various risk factors.
Results: There was statistically significant difference between the parameters such as BMI, waist circumference, waist hip ratio and family history of CAD and T2DM (P<0.05). Triglycerides and LDL levels were highly significant (P<0.01). Serum hsCRP shows strong positive association with serum total cholesterol, triglycerides and LDL, negative correlation with HDL level. Maximum cases had serum hsCRP levels of more than 3 mg/l.
Conclusion: The present study shows that hsCRP levels are increased in CAD patients with T2DM, even with a relatively short disease duration of 2 years. There was a positive correlation of serum hsCRP with other cardiovascular risk factors like BMI, blood glucose and lipid parameters which was highly significant.

Keywords:
High sensitive C-reactive protein(hs-CRP), Coronary artery disease(CAD), Atherosclerosis, Lipid profile