International Journal of Clinical Biochemistry and Research


DIAGNOSTIC SIGNIFICANCE OF LIVER & RENAL FUNCTION TESTS (LFT& RFT) IN IRON OVERLOAD IN PATIENTS WITH β-THALASSEMIA MAJOR


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Author Details: Nishtha Saral, Mamta Rathore, V. D. Bohra, Madhuri Gupta

Volume : 2

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 27

Article End Page : 32


Abstract

Background: β-Thalassemia results from a defect in β-globin chain production and ranges from clinically silent heterogeneous thalassemia minor to severe transfusion dependent homozygous thalassemia major. After approximately one year of transfusion, iron begins to deposit in parenchymal tissues, which might cause damage to the parenchyma and organ function impairment. So, iron overload may be develop liver, kidney, heart and endocrine abnormalities.

Objectives: The aim of study was to correlate the early hepatic and renal complications in condition of β-thalassemia with serum iron and total iron binding capacity (TIBC) levels.
Method: In study 50 β-thalassemia major patients were compared with 50 normal healthy subjects as controls. Fasting serum iron, TIBC, LFT and RFT were estimated using standard kit methods. Data were statistically evaluated by Student’s t-test and Pearson’s correlation coefficient (r).
Result: A significant increase in the levels of serum iron and a significant decrease in TIBC in β-thalassemia patients were observed. Serum levels of liver enzymes (Aspartate transaminase, Alanine transaminase and alkaline phosphatase) were significantly higher in β-thalassemia patients as compared to controls. A significant decrease in total proteins and increase in serum bilirubin level was found in β-thalassemia patients. Serum urea and creatinine levels were significantly higher, but no change in levels of serum uric acid was found in β-thalassemia patients when compared to controls. There was significant negative correlation between serum iron and TIBC, total protein among patient group.
Conclusion: Iron overload due to frequent transfusions in β-thalassemia results in abnormal organ function tests. Proper and timely screening of these parameters can help in early diagnosis & prevention of iron overload.

Key Words: β-thalassemia major, Iron, TIBC, SGOT, SGPT, ALP, Total protein, Urea, Creatinine, Uric acid