International Journal of Clinical Biochemistry and Research


CLINICAL AND HEMATOLOGICAL PROFILE OF PANCYTOPENIA


Full Text PDF Share on Facebook Share on Twitter


Author Details: Ridhi Agarwal, Vinay Bharat, B. K. Gupta, Shradha Jain, Rani Bansal, Ankur Choudhary, Gaurav Tiwari

Volume : 2

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 48

Article End Page : 53


Abstract

Background: Pancytopenia is a disorder in which all three cellular elements of blood (red blood cells, white blood cells & platelets) are decreased and this leads to triad of findings which includes anemia, leucopenia and thrombocytopenia. It can be due to reduction in hematopoietic cell production in the bone marrow due to infections, chemotherapy, parasitic infestation etc. The severity of pancytopenia and the underlying pathology determines the management and prognosis of the patients. Thus, identification of correct cause will help in implementing appropriate therapy.
Aims and Objectives: i) To evaluate haematological parameters in pancytopenic cases. ii) To classify pancytopenic cases on etiological basis. iii) To study various clinical presentations in pancytopenic cases.
Material and Methods: 70 pancytopenic patients were evaluated clinically, along with haematological parameters and bone marrow examination in the Department of Pathology, CSSH, Meerut, during the period of September 2011 to June 2013.
Results and Conclusion: Among 70 cases studied, all age group patients were included. Maximum number of patients were in the age group 11-20 yrs with female predominance. Most of the patients presented with fever and pain in legs. The commonest physical finding was pallor. In most of the patients Hemoglobin ranged between 5.1-8.0 g/dl, Total leucocyte count ranged between 1000-2500/cumm and Platelet count ranged between <5000-50,000/cumm. The commonest cause for pancytopenia was malaria (28.57%), followed by aplastic anemia (14.28%). In our study most common bone marrow finding (n= 23) was hypocellularity with aplastic anemia.

Key words: Pancytopenia, White blood cell, Red blood cell, Platelets