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International Journal of Clinical Biochemistry and Research


Evaluation of glomerular function in patients with type 2 diabetes mellitus


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Author Details: Asmabi M, Netravathi Basappa Sajjan, Tousif Devale, Shivaleela M Birasar, Shireen Quadri

Volume : 4

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 11

Article End Page : 14


Abstract

Background: The leading cause of chronic renal disease and end stage renal disease is diabetic nephropathy, so early recognition is very important. The important biochemical test for diagnosis of renal function is estimation of glomerular filtration rate (GFR). The accurate methods of GFR estimation are Inulin clearance and 24h urine collection, which are expensive and time consuming and require experts to perform. Hence some formulas have been developed for the GFR measurement.
Objective: To find out the prevalence of renal dysfuntion based on the levels of serum creatinne and estimated GFR, calcuted using Cockcroft-Gault (CG) and Modification of Diet in Renal Disease (MDRD) equations in type 2 diabetic patients.
Materials and Methods: A case control study was carried out on 50 type 2 diabetic patients and 50 healthy controls. Renal function was analyzed through serum creatinine and GFR estimated using the CG and MDRD equations.
Results: Among the 50 diabetic patients, 34% show high level of serum creatinine i.e. > 1.4 mg/dl, while the low eGFR that is < 90ml/mim is seen in 58% of diabetic patients by MDRD equation and 64% of patients by CG equation. The mean serum Creatinine level is significantly high p value (<0.001) in diabetic patients when compared with controls. The eGFR is significantly low p value (< 0.001) in diabetic patients when compared with controls.
Conclusion: The prevalence of renal dysfunction based on serum creatinine level is low when compared with eGFR by MDRD and CG equation, indicating the significance of these equations in estimating GFR. Hence for the better assessment of renal function these equations can be used as compliment to the levels of serum creatinine alone.

Keywords: Diabetes mellitus, Diabetic nephropathy, Glomerular filtration rate, Modification of Diet in Renal Disease, Cockcroft-Gault