Volume : 4
Issue : 1
Online ISSN : 2394-6377
Print ISSN : 2394-6369
Article First Page : 30
Article End Page : 32
Objective: To study the effects of subclinical and overt hypothyroidism on serum levels of low density lipoprotein(LDL), total cholesterol(TC), high density lipoprotein (HDL) and triglycerides(TG). And also to compare the results with normal healthy individuals and with previously published reference data. Lipid profile was estimated in 119 cases of subclinical hypothyroidism and 46 cases of overt hypothyroidism patients attending OPD of a major tertiary health care centre in Punjab.
Method: The study was done in the department of Biochemistry, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar. The serum TSH, FT3, FT4 was done by enhanced chemiluminescence technique using vitros Eci- ortho Clinical Diagnostics and lipid profile on semi autoanalyser. The cases were divided into two groups after studying the thyroid profile i.e. subclinical hypothyroidism characterized by elevated serum TSH with normal FT4 and overt hypothyroidism characterized elevated TSH with low FT4.The values of lipid profile parameters was compared in patients and normal healthy individuals.
Results: The descriptive data was given as mean ± standard deviation. The statistical analysis was done by ANOVA and student t test. Although in subclinical hypothyroidism the mean serum levels of total cholesterol, LDL was high as compared to controls but the difference was not statistically significant. The mean levels of total cholesterol and LDL in patients of overt hypothyroidism was higher as compared to controls. And the difference was statistically significant.
Conclusion: Thyroid diseases can have important effect on serum levels of total cholesterol, LDL, HDL and triglycerides. So, biochemical investigations such as serum FT4, FT3, TSH for thyroid dysfunction should be done in all patients having abnormal lipid profile so that the underlying thyroid disorders can be correlated and necessary intervention can be done as early as possible. Moreover this test is cost effective method for screening thyroid dysfunctions as compared to other investigations.