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International Journal of Clinical Biochemistry and Research


Evaluation of serum lipid profile in patients with hyperthyroidism


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Author Details: Anju Sharma, Jaskiran Kaur, Amandeep Kaur, Neha Uppal, Mandeep Kaur

Volume : 4

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 126

Article End Page : 128


Abstract

Introduction: Thyroid dysfunctions are known to influence lipid metabolism significantly, affects lipoprotein metabolism. Hyperthyroidism is associated with lipid alterations mainly concerning total and LDL cholesterol.
Materials and Method: It was a case control study. The cases and controls were screened for serum thyroid profile and complete lipid profile, the values were compared with that of normal healthy subjects. The cases were divided into two groups after studying the thyroid profile i.e. subclinical hyperthyroidism (characterized by low serum TSH with normal T4) and overt hyperthyroidism (characterized by low TSH and with elevated FT4).
Results: The descriptive data was given as mean ± standard deviation. The statistical analysis was done by ANOVA and student t test. The mean difference was significant at the 0.05 level and statistically insignificant when the p value obtained was greater than 0.05. The mean serum total cholesterol & LDL levels were decreased in patients of overt hyperthyroidism as compared to controls and the difference between the levels was statistically insignificant. But the mean serum TG remain unchanged in patients and the difference was statistically insignificant. In the cases of subclinical hyperthyroidism the mean serum levels of total cholesterol, LDL & TG were decreased in patients as compared to controls & the difference was statistically insignificant. But the mean serum HDL levels was significantly decreased in patients as compared to controls.
Conclusion: Thyroid function test for screening of thyroid dysfunction is great importance in all dyslipidemic patients. It is also of cardinal importance in all patients with unexpected improvement or worsening of their lipid profile. So underlying thyroid disorders should be recognized and treated in patients with dyslipidemia especially when the results are unforeseen.

Keywords:
Thyroid dysfunction, Hyperthyroidism, Lipid profile, Dyslipidemia