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International Journal of Clinical Biochemistry and Research


Association of total plasma homocysteine levels in hypothyroid individuals


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Author Details: Renuka P., Amuthavalli V., Umamaheswari V.

Volume : 4

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 145

Article End Page : 148


Abstract

One of the major complication of hypothyroidism is atherosclerosis and cardiovascular disease. Hyperhomocysteinemia is an important and independent risk factor for atherosclerosis. Hypothyroidism decreases hepatic levels of enzymes which converts homocysteine to methionine that leads to increase in homocysteine level in the circulation of hypothyroid individuals. The aim of the study was to assess fasting total plasma homocysteine level in recently diagnosed hypothyroidism. The study included thirty recently diagnosed hypothyroid individuals, thirty treated hypothyroidism and thirty apparently healthy subjects with age and sex matched. The study group was selected after obtaining ethical committee clearance and consent from subjects attending outpatient department of Endocrinology, Madras Medical College, Chennai. Thyroid profile and homocysteine were measured in fasting blood samples. Total plasma homocysteine level was significantly more in recently diagnosed hypothyroidism compared to controls and treated hypothyroidism with p value 0.006. By this study we confirmed hyperhomocysteinemia in hypothyroidism which may lead to atherosclerosis. Hypothyroidism is one of the treatable cause for hyperhomocysteinemia. During treatment with thyroxine, hypothyroid patients should be monitored for total plasma homocysteine levels. In hypothyroidism, estimation of total plasma homocysteine level can be used as screening test to identify and monitor cardiovascular risk.

Keywords:
Homocysteine, Hypothyroidism, Homocysteine & Cardiovascular Risk