International Journal of Clinical Biochemistry and Research


Investigating pre and post-operative blood gases and serum electrolyte in patients undergoing coronary artery bypass surgery (CABG)


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Author Details: S.S. Pramanik, K.N. Harley, R.K. Jambhulkar, R.K. Das, J.S. Sathe

Volume : 4

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 149

Article End Page : 153


Abstract

Background: Arterial blood gas analysis is a common investigation exercised in emergency room and ICU. In post-operative CABG patients, acid base alterations is the commonest problem encountered. Thus, constant check on these parameters is necessary to minimize post-operative mortality.
Aim and Objectives: To document the pre-operative and post-operative ABG, hemoglobin and serum potassium in patients undergoing CABG.
Materials and Method: Present observational study was conducted on 27 patients (Male=12 & Female=15) in the department of clinical biochemistry and cardiovascular thoracic unit at GMC-SSH, Nagpur. Fresh Arterial blood Samples were collected in dept. of biochemistry for ABG, hemoglobin and serum potassium pre-operatively and post operatively. Data were expressed in mean and standard deviation. Level of significance was expressed in P value applying student paired “t” tests.
Results: Findings suggested significant decrease in PaO2, in post-operative 5th & 9th day (P=0.0001) as compared to pre-operative Pa02.Raised PH observed on 5th and 9th day following CABG. Non-significant PaC02 changes in pre and 1st day following CABG.
However, significant drop observed in PaCO2 on 5th and slight improved PaC02 on 9thday but still significant changes as compared to pre-operative values (P=0.001). Extremely Significant (P=0.0001) decrease in Serum potassium (K+) and Hemoglobin (Hb) and hematocrit observed on 1st and 5th post-operatively as compared to pre-operative, However, improved serum K+ (p=0.03) and Hb (p=0.02 )demonstrated on 9th day following CABG but still quite significantly decreased.
However, when compared in female and male patients in pre and post-operative state, non-significant PH, alterations in PaO2,PaCo2, potassium (K+) and hemoglobin was significant between male and females.
Conclusion: Pre and post-operative serial ABG analysis is most important parameters to know status of acid base imbalance amongst CABG patients. By knowledge of ABG, one can manage post-operative CABG complications, provided ABG should be interpreted properly by physician.

Keywords:
Coronary Arteries Bypass Graft, Pre and Post-operative ABG, Serum Potassium