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International Journal of Clinical Biochemistry and Research


Creatine kinase & lactate dehydrogenase activity in patients with hypothyroidism


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Author Details: R. Shanti, M. Vijayalakshmi, R. Mahalakshmi

Volume : 4

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 182

Article End Page : 186


Abstract

Thyroid hormone exerts its action in all tissues and modulates several metabolic activity. Alteration in thyroid levels has a profound effect on skeletal muscle The aim of this study is to study the association of thyroid levels and the activities of serum creatine kinase (CK) and lactate dehydrogenase (LDH) in hypothyroidism and to correlate the relationship between CK, LDH and Thyroid Stimulating Hormone (TSH) levels.
Materials and Method: In this case control study, thyroid function tests, serum creatinine, CK and LDH activities were measured in 50 cases in the age group of 20-55years of overt hypothyroidism and the results obtained were compared with 50 healthy euthyroid controls. Patients with impaired renal function, ischemic heart disease, rheumatoid arthritis, Duchenne’s muscular dystrophy, polymyositis and other neuromuscular disorders, patients with drug history like statins, non-steroidal anti-inflammatory drugs, steroids, oral contraceptives, recent history of intramuscular injections or strenuous physical activity were ruled out.

Results: The mean serum levels of CK activity in hypothyroid patients was 224.94.2±76.7 IU L compared with 107±30 U L in euthyroid controls. The mean serum concentration of LDH was 346±33.8 IU L with overt hypothyroidism and 176.18±33.64 in controls. In the hypothyroid patients, a moderate positive correlation was found between CK activity and TSH (r = +0.517, p = 0.001), and a weak positive correlation between TSH activity and LDH (r = +0.331, p = 0.018).

Conclusion: There was a significant elevation in serum CK and LDH activities in hypothyroid individuals. These simple serum markers can be used for diagnosing musculoskeletal involvement in hypothyroid patients.

Keywords:
Hypothyroidism, Creatine Kinase, Lactate Dehydrogenase, Myopathy