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International Journal of Clinical Biochemistry and Research


Salivary Malondialdehyde and Uric acid in Tobacco Chewers


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Author Details: Sushama Dhonde, Miss Lizelle Rodrigues, Pratap Jagtap, G.J. Belwalkar, Vinayak Mane

Volume : 4

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 210

Article End Page : 212


Abstract

Introduction: Tobacco in any form is responsible for the generation of free radicals which cause oxidative damage, producing lesions in the mouth like ulcers, leukoplakia, erythroplakia, sub mucus fibrosis and is responsible for the progression of oral cancer. We aimed to find out the use of salivary malondialdehyde as a marker of oxidative stress, and salivary uric acid as a antioxidant, in the tobacco chewers.
Materials and Method: 60 healthy tobacco chewers and 60 healthy non chewers were included in the study. Salivary MDA was measured by method of K. Satoh, and Salivary Uric acid with the help of Biochemistry analyzer.
Results: The mean concentration of salivary MDA of control group was 0.0179 ± 0.008 and of study group was 0.073 ± 0.140 n moles/L. The increase in the MDA was statistically significant (p < 0.004). Salivary uric acid concentration of control group was 1.97 ± 1.38 and of study group was 2.11 ± 1.41mg/dl. The difference was not statistically significant (p > 0.05).
Discussion: Oxidative stress increased by the use of tobacco, leads in the increased lipid peroxidation followed by increased malondialdehyde. This may be the cause for the significantly increased salivary malondialdehyde concentration in the study group. Increased mean uric acid levels, though nonsignificant, may indicate initial phase of cellular injury.
Conclusion: Present study suggests that increased concentration of salivary Malondialdehyde and uric acid may be used as screening tool in tobacco chewers, for cellular injury.

Keywords:
Salivary MDA, Salivary Uric acid, Tobacco Chewers