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International Journal of Clinical Biochemistry and Research


A study of serum levels of magnesium and C-Reactive Protein in Type 2 Diabetes Mellitus


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Author Details: Rina Raibhan Wasnik, Veerabhadra Goud GK, DHSV Sarma, KP Joshi, Nagalakshmi CS

Volume : 4

Issue : 3

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 309

Article End Page : 314


Abstract

Type 2 Diabetes Mellitus (DM) has emerged as a major public health issue associated with various complications. Patients with metabolic syndrome (MS) have increased risk of developing cardiovascular disease and type 2 diabetes mellitus. C-reactive protein (CRP) correlates with individual components of metabolic syndrome and confer cardiovascular and metabolic risk. Magnesium is an essential ion involved in glucose homeostasis at multiple levels. Hypomagnesaemia has been reported in both IDDM and NIDDM patients. The present study is aimed to find the level of serum magnesium and CRP in type 2 diabetes mellitus and their association with development of metabolic syndrome and further development of type 2 diabetes mellitus. We have undertaken study on 120 subjects, categorized into three groups were involved in the study. FBS, lipid profile, serum magnesium and serum CRP levels were estimated in addition to recording of BP and anthropometric measurements.
Results: Serum magnesium levels were towards lower limit of normal range in both T2DM and MS groups with respect to controls. Further, serum CRP levels were elevated to nearly two times in T2DM and MS groups.
Conclusion: Our study findings suggest that serum magnesium and CRP levels are inversely related inflammatory markers are independent of Type 2 DM. This study could help in further studying degree of Hypomagnesemia and correlated elevation in CRP levels. Moreover, dietary supplementations of magnesium and/or other nutrient should be tried in case of Metabolic Syndrome along with assessment of Magnesium, CRP or other markers, in view to control these end stage pre diabetes condition from the development of Type 2 DM and to reduce the mortality resulting from cardiovascular diseases.

Key Messages:
Serum magnesium levels were significantly decreased in T2DM & Metabolic Syndrome. Serum CRP levels were significantly increased in T2DM & Metabolic Syndrome.

Keywords:
CRP, Lipid profile, Magnesium, Metabolic Syndrome, Type 2 Diabetes Mellitus

Doi No:-10.18231