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International Journal of Clinical Biochemistry and Research


Association between type 2 diabetes mellitus and hypovitaminosis D


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Author Details: Saleha Shaheen, Hamanshu Chauhan, Neha Mishra

Volume : 4

Issue : 4

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 413

Article End Page : 415


Abstract

Introduction: Vitamin D is an important component in regulating the biological functions of the body in various ways. Many studies repeatedly explained the role of vitamin D in the pathogenesis and treatment of various diseases. Recent studies proved a correlation between vitamin D deficiency and prevalence of Type 2 Diabetes and its complications.
Objective: to find out the possible correlation between Vitamin D and T2DM. Mainly in this study we have tried to correlate serum 25(OH) D levels with HbA1c levels.
Materials and Method: The present study was carried out in the Department of Biochemistry on 120 subjects patient in the age group of 35-70 years, attended OP in Hind Institute of Medical Sciences. Among them 60 healthy subjects enrolled as control group remaining 60 T2DM patients were served as case group. Serum 25hydroxyvitamin D levels were estimated by chemiluminescence immunoassay (CLIA), glycosylated hemoglobin (HbA1c) was measured by IFCC method by using ALERA AFINION AS 100.
Results: The concentration of serum 25-OH vitamin D levels were significantly (p<0.0001) lower in cases (22.92±6.66) as compared to the controls (35.96± 8.46). There was negative correlation found between 25-OH vitamin D levels and glycosylated hemoglobin (HbA1c) in cases of type 2 DM.
Conclusions: Prevalence of hypovitaminosis D was appeared to be more common T2DM patients in compare to non diabetic healthy population. There is a negative correlation exists between serum 25 hydroxy vitamin D and HbA1C (glycemic Control).

Keywords
: Type 2 Diabetes Mellitus, HbA1C, Hypovitaminosis D