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International Journal of Clinical Biochemistry and Research


Comparative study of calculated lipid indices viz atherogenic index of plasma, atherogenic coefficient and lipid accumulation product over conventional lipid profile parameters as better predictors of atherosclerosis in obesity: A cross sectional study


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Author Details: Amruta Bakshi*,Jayshree Bavikar,Shilpa Asegaonkar

Volume : 6

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 2

Article End Page : 6


Abstract

Introduction: Rising prevalence of obesity represents rapidly growing threat for Indian subcontinent. Dyslipidemia in obesity accelerates the process of atherogenesis; though its occurrence can’t be underestimated in apparently normal individual lipids. This warrants need of precise measures to predict dyslipidemia beyond routine lipid parameters. Atherogenic Index of Plasma, Atherogenic Coefficient & Lipid Accumulation Product have gained attention in this regard.
Aims and Objectives: This cross sectional study aimed at assessing usefulness of calculated lipid indices over individual lipids as potential predictors of atherosclerosis in obesity.
Materials and Methods: The study enrolled 100 apparently healthy overweight & obese cases and 100 healthy controls. Fasting blood sample was collected for lipid profile parameters. Statistical analysis was done by SPSS software.
Results: The levels of TC(211.4+ 36.2/173.9+21.4), TAG (162.9+41.5/124.6+26.3), AIP (0.23+0.11/0.08+0.03), AC (4.3+1.4/2.7+1.1) & LAP (31.3+8.6/24.3+6.2) were elevated while HDL (41.7+9.2/ 52.2+8.3) levels were founder to be low in cases compared to controls (p<0>Cases having raised AIP and LAP outnumbered than those with atherogenic dyslipidemia.
Conclusion: Calculated lipid indices proved to be better than conventional lipid parameters as simple, sensitive & independent tools to screen high risk individuals for atherogenesis in obesity especially in Indian scenario with limited resources.

Keywords: Obesity, Atherogenic index of plasma, atherosclerosis, Lipid accumulation product, Atherogenic coefficient.

Doi :-https://doi.org/10.18231/2394-6377.2019.0002