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International Journal of Clinical Biochemistry and Research


Correlation of Urinary Markers and Urine Creatinine in Glomerulopathy at the Onset of Type –II Diabetic Subjects


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Author Details: Gajraj Singh Yadav, Gora Dadheech Acharya, Meenu Rai, Archana Shrivastava

Volume : 2

Issue : 3

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 130

Article End Page : 139


Abstract

Background: Diabetic glomerulopathy in hyper glycemic state impaired kidney filtrations. Micro albuminuriais primary urinary marker simply indicating kidney dysfunction. IgG and transferrins are authenticating urinary markers of kidney dysfunction. High urine creatinine (Crt)) is waste product of unusual high protein metabolism.

Materials and Methods: The present study was conducted over 400 diabetes mellitus type –II (DMT-II) complicated patients; they were randomly selected on micro albuminuria using dipstic method. Urinary markers: Albumin (Alb), Immunoglobulin G (IgG), Transferrin (Trf), and Urine Crt were analyzed using enzyme linked immunosorvant assay (ELISA) kit method and Jaffe’s reaction respectively. Statistical analysis was performed using IBM, SPSS version 20.0 (Illinois). Data was expressed as mean ± S.D., Correlation between parameters was assessed using Pearson’s correlation coefficients (r) by linear regression analysis.
Result: 276 patients were reported as hyperalbuminic (More than normoalbuminuria 30mg/day) cases among 400 DM type-II complications. 55.15%hyperimmunoglobulinic-G(more than normal level of IgG) and 67.88 % hyper transferrinic cases were reported and found positive correlation between Crt & Alb (r2 = 0.561, P-0.01), Crt & Trf (r2 = 0.142, P-0.01), Crt & IgG (r2 = 0.205, P-0.01).

Key worlds: Urinary markers, transferrin, IgG, creatinine