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International Journal of Clinical Biochemistry and Research


Vitamin D Status in Type 2 Diabetes Mellitus


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Author Details: Lakshmi G, Jothimalar, Santhi Silambanan

Volume : 2

Issue : 3

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 140

Article End Page : 142


Abstract

Background: Type 2 Diabetes Mellitus (T2DM) is a progressive disease characterized by both insulin resistance and β-cell dysfunction. Several studies have revealed the inverse relationship between vitamin D deficiency and T2DM. Vitamin D deficiency is thought to influence insulin resistance and the pathogenesis of T2DM by affecting either insulin sensitivity or β-cell function or both. It has been shown that vitamin D replenishment improves insulin sensitivity in patients with T2DM and also decreases the progression of diabetic neuropathy. The presence of vitamin D receptors (VDR) and vitamin D binding proteins (DBP) in pancreatic tissue and the relationship between certain allelic variation in the VDR and DBP genes with glucose tolerance and insulin secretion have further supported this hypothesis.

Aim: To examine the association between vitamin D deficiency and T2DM.
Materials and Methods: The Study design is a case-control study. 60 non-diabetic individuals were taken as controls and 60 individuals with known DM were taken as cases. Each group consisted of both sexes and the participants were between age of 30-60 years. Various parameters like plasma FBS, 2 hour PPBS, Serum levels of 25(OH)-vitamin D level were measured in both groups. The data were collected and analyzed.
Result: Vitamin D level was found to be significantly low in diabetic group compared with controls (p value<0.05)
Conclusion: There is inverse association between vitamin D status and Type 2 Diabetes Mellitus.

Key words: Vitamin D, TYPE 2 Diabetes Mellitus, Vitamin D receptor, Vitamin D binding protein