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International Journal of Clinical Biochemistry and Research


Neutrophil to Lymphocyte Ratio as an Indicator of Presence of Coronary Artery Disease in Diabetic Patients


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Author Details: Mario Leesha Fernando, Santhi Silambanan, Jothi Malar

Volume : 2

Issue : 3

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 143

Article End Page : 147


Abstract

Background and Objectives: Cardiovascular disease is the leading cause of death in type 2 Diabetes mellitus (DM). Type 2 DM is a significant risk factor of atherosclerotic coronary artery disease. Neutrophil to Lymphocyte ratio (NLR), an indicator of systemic inflammation has been shown to provide a reliable inflammatory index to be used in prognostic stratification of CAD. The objective of this study is to investigate the relationship between neutrophil to lymphocyte ratio (NLR) and coronary artery disease (CAD) in diabetic patients.

Methods: 100 diabetic patients who had coronary lesion with diameter stenosis of at least 50% and 50 diabetic patients with normal coronary anatomy matched with age and sex were retrospectively selected and classified as CAD(+) and CAD(-) group respectively. Diabetics with chronic infections and inflammation were excluded. NLR in two groups were compared.
Results: NLR was higher in CAD (+) group compared to CAD (-) group (p = 0.000). ROC curve analysis revealed that NLR value of ≥ 2.26 identified the presence of CAD in diabetic patients with 100% specificity and 92% sensitivity.
Conclusion: NLR was higher in diabetic patients with angiographically proven CAD compared to those without CAD. NLR may serve as a useful marker to predict the presence of CAD in type 2 diabetic patients.

Key words: Diabetes mellitus, Coronary artery disease, Neutrophil to Lymphocyte ratio