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International Journal of Clinical Biochemistry and Research


Study of Paraoxonase, Catalase, HDL-Cholesterol and Malondialdehyde Levels in NIDDM


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Author Details: Anuradha Katti-Suryawanshi, Shailaja Avinash Katti, D.S. Jayaprakash Murthy, Abdul Kayum Shaikh

Volume : 2

Issue : 3

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 154

Article End Page : 161


Abstract

Diabetes Mellitus (DM) is an important cause of morbidity and mortality through its various complications. A decrease in Paraoxonase 1 (PON1) activity in diabetes is associated with occurrence of vascular complications. Our objectives were to estimate PON1 activity, Catalase (CAT) activity and Malondialdehyde (MDA) levels in Non-Insulin Dependent Diabetes Mellitus (NIDDM) cases and controls. We also had an objective to establish possible relationship between PON1, High Density Lipoprotein-Cholesterol (HDL- Cholesterol), CAT, MDA levels and to correlate CAT/PON1 ratio with Glycosylated Hemoglobin (HbA1c) levels.


Keywords: Diabetes Mellitus, Paraoxonase, Oxidative stress, CAT/PON1 ratio