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International Journal of Clinical Biochemistry and Research


Assessing the need for adjustment of first trimester screening markers in Diabetic Womenc


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Author Details: T.Spandana, Jnankumar Chaudhuri, Santhi Silambanan

Volume : 2

Issue : 3

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 190

Article End Page : 193


Abstract

Introduction & Objective: First trimester screening is done to detect aneuploidy pregnancies; the tests include serum Pregnancy Associated Plasma Protein A (PAPP A), free β subunit of human Chorionic Gonadotropin (β hCG) and Nuchal Translucency (NT) thickness. This study was done to compare serum PAPP A and free β hCG levels in diabetic and non-diabetic women with normal NT thickness, during first trimester aneuploidy screening and to assess the need for adjustment of screening markers in diabetic women.

Materials and Methods: The study design is cross-sectional involving 632 non diabetic and 55 diabetic women who underwent first trimester (11 to 13 weeks 6days) aneuploidy screening from January 2014 to June 2015 at Sri Ramachandra Medical Centre. Serum PAPP A and free β human chorionic gonadotropin were measured by solid phase, two site fluoroimmunometric assay.
Results: Results were analysed using SPSS software version 18. Serum PAPP A concentration in diabetic women were found to be significantly low compared to non-diabetic women (p < 0.000). There was no significant difference in free β hCG between two groups.
Conclusion: Significantly low MoM PAPP A in diabetic pregnant women may necessitate to consider for adjustment of PAPP A values while calculating individual aneuploidy risk.

Keywords: PAPP A, free beta hCG, anueploidy screening, Diabetes Mellitus.