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IP Indian Journal of Clinical and Experimental Dermatology

Does İsotretinoin (ISO) Therapy İncrease Coagulation Tendency? Evaluation of MPV values and MPV / platelet rate

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Author Details: Pinar Ozuguz, M. Sena Ulu, Seval Dogruk Kacar, Ufuk Ozuguz, Semsettin Karaca

Volume : 1

Issue : 1

Online ISSN : 2581-4729

Print ISSN : 2581-4710

Article First Page : 14

Article End Page : 16


Introduction/ Purpose: Mean Platelet Volume (MPV), an indicator of platelet activation, is a new risk factor for atherothrombosis and an important marker for the increase in thromboembolic diseases. MPV/ platelet ratio is considered as a risk factor for various diseases such as myocardial infarction. In this study, we aimed to investigate the possible effect of ISO on blood cell counts especially MPV and MPV/ platelet ratio.
Materials and Methods: 75 patients, between the ages of 18-25 with moderate or severe acne vulgaris and using oral isotretinoin (0.5 mg/ kg) were included in the study. Platelet count ​​and MPV values of patients (pre-treatment and 3 months after the treatment) were recorded retrospectively.
Results: The mean age of patients was 23.32+3.44 years. 40 patients were female and 35 were male. MPV levels and MPV/ p ratio of “before treatment period” were significantly higher than the “after treatment period” (p Conclusion: In the literature, alteration in platelet levels under ISO treatment is a controversial issue. Furthermore, it was emphasized that, ISO treatment may be change platelet functions. In our study, MPV values and MPV / p ratio were decreased after ISO treatment. Our data indicates that, the thromboembolic risk of patients with acne vulgaris may reduce after ISO treatment.

Acne vulgaris, İsotretinoin, MPV, PlateletThromboembolism risk