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IP Indian Journal of Clinical and Experimental Dermatology


Association of Metabolic Syndrome with Psoriasis Vulgaris: A Case Control Study


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Author Details: Harsh Sharma, Krishnendra Varma, Ujjwal Singh, Animesh Saxena

Volume : 2

Issue : 1

Online ISSN : 2581-4729

Print ISSN : 2581-4710

Article First Page : 12

Article End Page : 16


Abstract

 

Introduction: Psoriasis is a common, chronic, inflammatory, immune mediated, genetically determined skin disorder, the course of which is affected by multiple environmental factors. Psoriasis is associated with metabolic syndrome and its components, such as obesity, diabetes and hypertension independent of traditional risk factors for these disorders. These phenotypically diverse conditions share similar pathologic changes, selected susceptibility genes and loci.
Aim: To assess the association of Metabolic syndrome in patients of psoriasis vulgaris.
Objectives: 1. To select clinically diagnosed cases of psoriasis vulgaris.

2. To study and evaluate the profile of psoriasis vulgaris patients.

3. To compare the cases with age and sex matched control groups.

4. To study the association of psoriasis vulgaris with metabolic syndrome.

Study Design: Case Control study (200 cases and 200 controls).RESULTS: In our present study Metabolic Syndrome was present in 52(26%) of psoriatic cases in comparison to 20(10%) non psoriatic cases which came out to be statistically significant [Odds ratio (OR) - 3.162, Degree of freedom (df) –1, p – value-0.003, ? 2 -8.672].
Conclusion: There is possible association of metabolic syndrome with psoriasis.

Keywords:
Psoriasis, Metabolic Syndrome, TNF-alpha, hyperlipidemia, Hypertension, BMI