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IP Indian Journal of Clinical and Experimental Dermatology


Fixed drug eruption to cetirizine – role of patch testing


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Author Details: Sonia Raghukumar, Ravikumar BC

Volume : 2

Issue : 3

Online ISSN : 2581-4729

Print ISSN : 2581-4710

Article First Page : 122

Article End Page : 124


Abstract

Antihistamines are prescribed for a wide variety of disorders like urticaria, eczema, allergies and infestations. Adverse reactions due to them is unusual and the incidence of fixed drug eruption is scarce. They are characterized by a sudden onset of edematous, erythematous plaques appearing at the same sites following an oral provocation with the drug and is proposed to be due to the epidermal CD8+ T cells resident at the sites of these residual post inflammatory hyper pigmented macules. Antihistamines sharing a similar chemical structure have an increased likelihood of showing cross reactions and a patch test based evaluation can be carried out to deduce the offending drugs, cross reactions and alternative medications.

Keywords:
Antihistamines, Fixed drug eruptions, Patch testing