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Indian Journal of Clinical and Experimental Ophthalmology


The comparison of intraocular pressure lowering efficacy of 0.5% timolol maleate versus 0.0015% tafluprost in cases of primary open angle glaucoma and ocular hypertension


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Author Details: Gursatinder Singh, Navneet Kaur, Ankush Bhagat, Anita K. Gupta

Volume : 2

Issue : 2

Online ISSN : 2395-1451

Print ISSN : 2395-1443

Article First Page : 83

Article End Page : 86


Abstract

Objectives: To  compare the  intraocular pressure lowering efficacy of 0.5% timolol maleate versus 0.0015% tafluprost in cases of primary open angle glaucoma and ocular hypertension.
Methods and Materials: This prospective, open, randomized, parallel group study was conducted in 80 newly diagnosed primary open angle glaucoma (POAG) and ocular hypertension (OHT) cases which were randomized into two groups (I and II) of 40 cases each and received 0.5% timolol maleate and 0.0015% tafluprost respectively. Efficacy of the drugs was calculated as mmHg lowering in mean IOP observed at the end of 3 months and the observations made in both groups were compared using appropriate statistical tools.
Results: IOP at the different time points assessed during the baseline visit ranged from 24.27 to 25.10 mmHg, with a mean of 24.60 mmHg in group I and 24.65 to 25.45 mmHg, with a mean of 25.04 mmHg in group II. IOP at various time points assessed after 12 weeks ranged from 18.12 to 18.60 mmHg, with a mean of 18.36 mmHg for group I and 16.52 to 17.47 mmHg, with a mean of 16.97 mmHg for group II. Mean diurnal IOP reduction with timolol and tafluprost was 6.24 mmHg (25.37%) and 8.07 mmHg (32.23%) respectively, with the difference being statistically significant.
Conclusions: There is significant difference in IOP lowering efficacy between the two groups with tafluprost consistently achieving greater reduction in IOP as compared to timolol.

Key-words:
Glaucoma; IOP; Ocular hypertension; POAG; Tafluprost; Timolol