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Indian Journal of Clinical and Experimental Ophthalmology


Role of cyclosporin 0.1% in perennial vernal keratoconjunctivitis


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Author Details: Kshama Dwivedi, Arun Kumar Singh, Vanlalhruaii Hauhner, Mimansaa Agasti

Volume : 2

Issue : 3

Online ISSN : 2395-1451

Print ISSN : 2395-1443

Article First Page : 190

Article End Page : 194


Abstract

Introduction: To evaluate the efficacy of topical cyclosporin A 0.1% eye drops in management of moderate to severe perennial vernal keratoconjunctivitis.
Methods: Fourteen patients with moderate to severe perennial vernal keratoconjunctivitis, who were dependent on steroid eye drops for control of disease, were administered 0.1% cyclosporin A eye drops twice a day. Signs, symptoms and steroid score were calculated at start of study, and then at two monthly interval.
Results: Ten males and four females, between age of 3 – 17 years were enrolled in this study. Treatment with cyclosporin A 0.1% eye drops decreased the symptom, sign and steroid score at 12 months (p<0.0001, paired t test). Steroid sparing effect was seen in five patients at the end of study period.
Conclusions: Topical cyclosporin A 0.1% eye drops can be used as a steroid sparing agent in the management of perennial vernal keratoconjunctivitis.

Keywords:
Cyclosporin A, Perennial vernal keratoconjunctivitis