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Indian Journal of Clinical and Experimental Ophthalmology


PREDICTORS OF VISUAL RESPONSE TO INTRAVITREAL BEVACIZUMAB FOR TREATMENT OF DIABETIC MACULAR EDEMA


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Author Details: Sunny Kumar Gupta, Ishan Yadav, Sujit Deshmukh, Rajendra P Maurya, V P Singh

Volume : 1

Issue : 1

Online ISSN : 2395-1451

Print ISSN : 2395-1443

Article First Page : 35

Article End Page : 40


Abstract

Objective: To evaluate which factors influence maximum gain in best-corrected visual acuity after intravitreal injection of Bevacizumab as treatment for diffuse diabetic macular edema.
Methods: This was a prospective, interventional trial including 112 eyes of 100 participants. Visual outcomes measured by change in visual acuity (VA) score, proportion gaining ≥15 letters, and change in central retinal thickness (CRT), presence of macular ischaemia, IS/OS integrity.
Results: Mean change in the VA score was 9.2 ± 2.3 SD letters with a total of 79 eyes gaining ≥15 letters. Change in median CRT was 81.5 𝜇m. Younger age, higher baseline VA score, shorter duration of Diabetic Macular Edema (DME), absence of macular ischemia and an intact IS/OS junction were significantly associated with greater VA score improvement.
Conclusion: Pronounced macular edema and intact IS/OS junction may have a positive impact, and marked macular ischemia and a high preoperative best-corrected visual acuity may have a negative impact, on an increase in best-corrected visual acuity after intravitreal Bevacizumab injection in patients with diabetic macular edema.
Key Words: Bevacizumab, Diabetic macular edema, IS/OS junction, Macular ischaemia.