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Indian Journal of Clinical and Experimental Ophthalmology


A study to determine association of serum uric acid level with age related macular degeneration


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Author Details: Dhaval Patel, Harsha Bhattacharjee, Shriya Dhar, Divakant Misra, Eknath Pawar

Volume : 3

Issue : 2

Online ISSN : 2395-1451

Print ISSN : 2395-1443

Article First Page : 142

Article End Page : 146


Abstract

Aim: To study the association of serum uric acid level with age related macular degeneration, if any.
Materials and Method: In this hospital based, observational, case control study, 100 patients presenting to our out patient department over a period of one year were included. The selected participants were grouped into the ARMD group which included 50 eyes with non neovascular ARMD and neovascular ARMD) and 50 eyes in control group. All participants were undergone complete ophthalmic evaluation along with serum uric acid level determination.
Results: 50 eyes of 50 patients diagnosed as having AMD and 50 eyes of 50 patients do not having AMD who served as a control were included in this study. The mean age was 66 years (49-85years). On an average higher serum uric acid were observed amongst males as compared to females (median: male vs female kruskal Wallace test H=22.5, DF=1, p<0.001).The average serum uric acid level were higher in patients with neovascular AMD (mean=505.00 ± std dev =13.57 mmol/l, n=19), than in the non-neovascular AMD (mean=322.93 ± std dev =26.26mmol/l, n=31),as compared to control group =318.42 ± std dev =76.23 mmol/l,n=50). On comparing the standardized serum uric acid level between neovascular AMD and control group, there was a statistically significant difference was observed. (H=40.734, DF=1, p<0.001).
Conclusion: A statistically significant correlation exists between serum uric acid level and severity of age related macular degeneration. Patients with neovascular age related macular degeneration present with a higher serum uric acid level as compared to patients with non neovascular age related maculae degeneration. Also, males had a significantly higher serum uric acid level as compared to females.

Keywords:
Neovascular age related macular degeneration, Non neovascular age related macular degeneration, Serum uric acid level.

Doi No:-10.18231