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Indian Journal of Clinical and Experimental Ophthalmology


Comparison of endothelial cell characteristics and corneal thickness between diabetics and non-diabetics


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Author Details: Minu Ramakrishnan, Saba Kausar, Mayur Agarwal

Volume : 3

Issue : 2

Online ISSN : 2395-1451

Print ISSN : 2395-1443

Article First Page : 150

Article End Page : 153


Abstract

Objectives: To compare endothelial cell characteristics & corneal thickness between diabetic and non-diabetic population.
Materials and Methods: This was a prospective, non-interventional, cross sectional study where 200 consecutive patients with diabetes mellitus and 100 controls were examined. Complete medical history was taken and ophthalmologic examination was done, including best corrected visual acuity tested by Snellen’s chart, intraocular pressure using applanation tonometer, slit-lamp examination, endothelial cell count and morphology (using non-contact specular microscopy) and central corneal thickness and binocular indirect ophthalmoscopic fundus examination. Patients with diabetic retinopathy were graded according to Early Treatment Diabetic Retinopathy Study (ETDRS) study. Data obtained was grouped and analysed.
Results: The mean endothelial cell count in diabetic group was significantly lesser than that in the control group. (p=0.000). Also a reduction in the mean percentage of hexagonal cells was seen in diabetic group. (p=0.000)
Whereas the mean corneal thickness in diabetic group was found to be more than that in the control group. (p=0.000). And we also found that there was a significant increase in the mean coefficient of variation in diabetic group as compared to control group.(p=0.000)
Conclusion: The mean endothelial cell count is significantly lower in diabetics as compared to non-diabetics. The mean corneal thickness and also the mean coefficient of variation in diabetics is higher than the non-diabetics, but the mean percentage of hexagonal cells in diabetics is reduced.

Keywords:
Corneal thickness, Endothelial cell count, Diabetic, Non-diabetic