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Indian Journal of Forensic and Community Medicine


Effect of anti-retroviral therapy on cd4count in treatment naive HIV infected patients attending anti retro viral therapy centre in north Karnataka


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Author Details: Bharatesh Devendra Basti, Girish B

Volume : 3

Issue : 2

Online ISSN : 2394-6776

Print ISSN : 2394-6768

Article First Page : 101

Article End Page : 107


Abstract

Background: ART treatment has resulted in a marked decrease in the mortality and morbidity associated with HIV infection. Follow-up and monitoring is essential in patients initiated on ART to track clinical progress and monitor wellbeing.
Objectives: 1. To determine the effect of Anti-retroviral Therapy (ART) on CD4 Count in treatment-naïve HIV/AIDS patients. 2. To determine the effect of ART on Weight gain and haemoglobin percentage in treatment-naïve HIV/AIDS patients.
Materials & Methods: Longitudinal study was conducted at the ART centre, North Karnataka for a period of 1 year among 242 HIV infected patients. CD4 count, haemoglobin, weight, etc were measured at the time of initiation of ART and at the end of 6 months of ART. 
Statistical analysis: Data analysed using Epi-Info 6 software. Tests used were mean, proportions, Chi square test and Paired T test.
Results: 54(22.3%) were in the age group of 25-29 years, 133(55%) were females and 109(45%) were males. Male to female ratio is 1:1.2. CD4 counts >200 cells/mm3 at the initiation of ART were in 82 (33.9%) patients and at the end of 6 months were in 187 (85%) of patients.  Increase in the CD4 counts was noticed in 206 (95.8%) patients after 6 months of ART. Significant increase in the mean CD4 count by 165.7182 cells/mm3, mean CD4 percentage by 7.3591% & weight by 2.4727 kg were noted.
Conclusions & Recommendations: CD4 counts and CD4 percentage in HIV patients increase substantially with proper ART. Initiation of ART at an earlier stage has significant better results than wait for the counts to lower.

Key Words:
Anti-Retroviral Therapy, CD4 Count, HIV infection