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IP Indian Journal of Immunology and Respiratory Medicine


A study on the levels of IgE as a biomarker in the management of bronchial asthma patients


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Author Details: Kavitha Devi M, Yuvarajan S, Vickram Reddy, Kalaikovan B

Volume : 1

Issue : 3

Online ISSN : 2581-4222

Print ISSN : 2581-4214

Article First Page : 58

Article End Page : 62


Abstract

Background: IgE is a major contributing factor for the development of bronchial hyper responsiveness in asthmatics. Serum IgE levels also shows association with degree of airflow obstruction. Therefore, a study was undertaken to estimate the serum IgE level in bronchial asthma patients, and to correlate the severity of airway obstruction with serum IgE level in bronchial asthma patients. A total of 75 cases in the age group of 21-60 years, of Tertiary care Hospital, Madagadipet, Puducherry-India was included in the study. Spirometry with reversibility testing was done in all cases. Serum IgE level was estimated using Quantia IgE, which is a turbid metric immunoassay. Patients with bronchial asthma had elevated serum IgE, which increased with increase in the severity of airflow obstruction and it was found to be statistically significant (p <0.05). It was concluded that Serum IgE level increases as the severity of airflow obstruction increases. It helps to classify the Bronchial asthma patients based on IgE and to guide anti IgE therapy for the patients with difficult to treat allergic asthma and to assess its response.

Keywords:
Allergic asthma-; Serum IgE; Severity of obstruction; Spirometry-IgE therapy